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Mary of Guise, also called Mary of Lorraine 1515-60
French noblewoman and Scottish queen

The daughter of Claude of Lorraine, 1st Duke of Guise, she married Louis d'Orléans, Duke of Longueville (1534), and James V of Scotland (1538), at whose death (1542) she was left with one child, Mary, Queen of Scots. During the troubled years that followed, she acted with wisdom and moderation, but after she was made Regent of Scotland (1554) she campaigned against Protestantism and allowed the Guises so much influence that the Protestant nobles raised a rebellion (1559), which continued until her death at Edinburgh Castle.